Targeting the untargetable cancer—rezatapopt, an oral p53 reactivator

Memorial Sloan Kettering Cancer Center investigators and collaborators have tested rezatapopt, an oral p53 reactivator ...

Acrivon Therapeutics Conference Highlights ACR-368 Phase 2B Data, 52% ORR in Serous Endometrial Cancer

Acrivon Therapeutics (NASDAQ:ACRV) hosted a webcast featuring a key opinion leader (KOL) panel focused on the company’s ...
European Medical Journal

CCN5 Protein Prevents Cardiac Cellular Senescence

CCN5 reduced cardiac cellular senescence in preclinical models of cardiovascular disease. Learn how this could shape ...

Flipons help Intrinsically Disordered Proteins Fold into Cellular Machines

Different DNA Structures Nucleate the Folding of Proteins to form specific complexes that modulate the readout of ...
eLife

Impacts of mutation accumulation and order on tumor initiation revealed by engineered murine colorectal cancer organoids

This study presents a valuable finding on the mutational order for common alterations in colorectal cancer. The evidence of in vitro growth assays comparing mutations is solid, although inclusion of ...
The Lancet

Safeguarding genomic integrity in pluripotent stem-cell therapies

Human pluripotent stem-cells (HPSCs)—including human embryonic stem-cells and human induced pluripotent stem-cells—are reshaping the landscape of regenerative medicine.1,2 In Parkinson's disease, ...
eLife

Coordinated stimulation of axon regenerative and neurodegenerative transcriptional programs by ATF4 following optic nerve injury

A secondary stress signaling pathway in the response to optic axon injury is an unexpectedly strong contributor to both neurodegeneration and axon regenerative potential.