Noxa is a proapoptotic BH3-only member of the Bcl-2 family, which binds specifically Mcl-1 (see Willis and Adam 6 for review). When its BH3 domain inserts within the hydrophobic groove of Mcl-1, this ...
Polychemotherapy involves the simultaneous application of various cytotoxic drugs. So far, effective drug combinations were selected empirically in clinical trials, while the mechanistic understanding ...
This is an ASCO Meeting Abstract from the 2009 ASCO Annual Meeting I. This abstract does not include a full text component.
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